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Role of Signaling Pathways in Brain Tumoriogenesis

Author: Mehdi Hayat Shahi

Publisher: Springer

ISBN: 9811584729

Category: Medical

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This book provides acomprehensive overview of cell signalling pathways and morphogens in the genesis of brain tumours. It also explains the role of brain tumour stem cells in the brain tumour progression. It also elucidates the novel early biomarkers that can be utilized to diagnose brain tumours. It presents the basic developmental pathways and morphogens, including retinoic acid and TGF-b that promote brain tumorigenesis. The chapters illustrate the role of stem cells and stem cells mediated cell signalling pathways including, Sonic hedgehog, Notch, Wnt in the brain tumour growth. The chapters also emphasize the role of transcription factors, mainlyNanog, Sox, BMI1, HIF1 and Pax6 in the brain tumouriogensis. It highlights the role of NF-kb, Myc and neurotrophins in the brain tumour development. Finally, the book summarizes the potential early therapeutic targets and targeted drug discovery for brain tumours.
Role of Signaling Pathways in Brain Tumoriogenesis
Language: en
Pages:
Authors: Mehdi Hayat Shahi
Categories: Medical
Type: BOOK - Published: 2021-02-26 - Publisher: Springer

This book provides acomprehensive overview of cell signalling pathways and morphogens in the genesis of brain tumours. It also explains the role of brain tumour stem cells in the brain tumour progression. It also elucidates the novel early biomarkers that can be utilized to diagnose brain tumours. It presents the
Caveolins in Cancer Pathogenesis, Prevention and Therapy
Language: en
Pages: 124
Authors: Isabelle Mercier, Jean-François Jasmin, Michael P. Lisanti
Categories: Medical
Type: BOOK - Published: 2011-11-03 - Publisher: Springer Science & Business Media

Caveolins are important structural proteins of Caveolae, small invaginations of the membrane. They have been shown to play an important role in the pathogenesis of multiple cancers. In this volume, we will mainly focus on the importance of Caveolin-1 in breast, prostate, lung, skin, colon, pancreatic and brain cancers with
The Role of P53 in the Regulation of Cancer Stem Cells of Glioblastoma
Language: en
Pages: 256
Authors: Michael Karsy
Categories: Medical
Type: BOOK - Published: 2014-02 - Publisher: LAP Lambert Academic Publishing

Glioblastoma (GBM) is the most common primary brain tumor and yields a poor prognosis despite current surgical, radiological and chemotherapeutic regimens. Recent studies have provided evidence that the presence of cancer stem cells (CSC) may be responsible for GBM regrowth, dissemination and resistance to therapy. Various genetic abnormalities have been
Cancer and Development
Language: en
Pages: 384
Authors: Michael Karsy
Categories: Medical
Type: BOOK - Published: 2011-03-28 - Publisher: Academic Press

In recent years, a number of molecular pathways and cellular processes that are essential for normal vertebrate development have been implicated in cancer initiation and progression. In this volume, leaders in the field of cancer genetics and developmental biology share recent insights into the importance of developmental pathways for tumorigenesis.
Stem Cells Between Regeneration and Tumorigenesis
Language: en
Pages: 340
Authors: Monica Neagu , Cristiana Tanase
Categories: Science
Type: BOOK - Published: 2016-09-16 - Publisher: Bentham Science Publishers

Experts in the field of cellular biology have shown that the reactivation of pluripotency inherent in all cells can allow us to reprogram cells into a specific cell line. This reprogramming paradigm is steadily enhancing our understanding of cell differentiation processes and cellular identity. Consequently, new prospects for cellular therapies